Quantum Genomics are the creators of Firibastat, a first-in-class brain aminopeptidase inhibitor (BAPAI) that could potentially treat treatment-resistant hypertension by acting in the brain to interfere with the renin-angiotensin system.
It is estimated that there are around 150 million people worldwide that are affected by treatment-resistant hypertension, resulting in almost 10 million deaths per year from complications due to high blood pressure. With such a high number of people dealing with this chronic condition (around 1.1 billion people). For those with treatment resistant hypertension, they can be more susceptible to complications associated with hypertension such as heart failure, coronary artery disease, stroke, kidney disease and peripheral artery disease.
Standard treatments for hypertension include extensive lifestyle changes to address potential factors that may have contributed to the disease and multi-drug regimens, based on preference of the treating doctor.
Firibastat works by crossing the blood-brain barrier and modulating the brain renin-angiotensin system (RAS). RAS is a hormone system that controls blood pressure in part by modulating dilation and constriction of the blood vessels throughout the body, there is a RAS system in the brain, and at the peripheral level (kidney, heart…). By modulating the brain RAS, Firibastat decreases vasopressin release, decreases sympathetic nerve activity and improves baroreflex. These effects lead to a vasodilatation and an increased diuresis, thereby decreasing blood pressure.
In the brain, Firibastat causes the inhibition of aminopeptidase A (APA) which is a key enzyme in the RAS. By inhibiting APA, Firibastat decreases levels of angiotensin III in the brain, a key protein that drives vasoconstriction. It is because of these actions that take place in the brain due to Firibastat that the drug could potentially address hypertension in the population of patients that have been resistant to current treatments of hypertension that act at the peripheral level.
Quantum Genomics has concluded NEW-HOPE, which is phase 2b trial in difficult-to-treat hypertension. The trial included 256 overweight and obese patients with primary hypertension across the US including 53% of minorities patients (of whom 38% of African-American) , 44% are female, and 26% are above the age of 65 years old. This kind of population is more likely to suffer from resistant hypertension
Indeed treatment-resistant hypertension is not equally common across all demographics and ethnicities and was more prevalent in black, Hispanic, elderly and female populations. Obese patients with hypertension were 5 times more likely to be resistant to treatment.
Results of the trial indicated that treatment with Firibastat for 8 weeks resulted in significant (p<0.0001) decreased office systolic blood pressure by 9.5 mmHg (from 153.9 down to 144.4 mmHg) and was determined to be safe. Firibastat’s efficiency was similar in black (-10.5mmHg) and non-black (-8.9mmHg) populations, contrary to other anti-hypertensive classes
The trial also showed a larger blood pressure decrease for patients with higher baseline hypertension, a predictive factor of resistant hypertension. Based on the outcome of the NEW-HOPE trial, Quantum Genomics will initiate a phase 3 pivotal trial in resistant hypertension with Firibastat.
Based in Paris and New York, Quantum Genomics trades on the OTCQXt in the United States and Euronext Paris.
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Singapore 2019. Mar.1- Longxing Global Mining Assets Digital Trading Platform attended The Block Challenge Event held by Dubai World Trade Centre(DWTC) in Singapore. During the event, Longxing announced that Longxing is officially listed on ExShell (token: LXS). The Longxing platform is the first digitized trading platform for mining assets based on blockchain in the world. Relying on blockchain technology, the Longxing platform recognized the upgrade from the traditional local offline trading mode to global online trading mode.
Depending on the technical advantage of the Longxing platform, cross-border transactions can be realized, purchasing qualifications can not be relied on, transaction thresholds can be lowered, liquidity and transaction efficiency can be improved, and transaction cycles can be shortened. As digital money payment has formed a good ecological environment, online iron ore, digital assets trading and linking to global mining assets intermediaries can not rely on traditional currency. In the future, with the help of the Longxing trading platform, online trading of iron ore, coal mine, non-ferrous metals, rare technology and other resources, will all launch on the blockchain and trading can be completed only with digital money.
Combining the latest technologies such as blockchain, Internet of things and AI, Longxing has cooperated with taoken bitcoin company to develop the global blockchain mining digital trading platform system. Based on the characteristics of mining, generating sales business process and mining assets, two blockchain systems are developed respectively: the system of business chain and the system of assets chain. Among them, the business chain system mainly needs to display company information, financial data, business and technology, production data, etc., and at the same time, give senior investors a real-time view of production and operation data; Assets on the chain system mainly include the creation of equity, audit and issuance functions, as well as information bulletin functions. Distributed nodes are located in issuers, law firms, accounting firms and all private investors, etc., providing investors with a transparent and untamable platform for operating data and assets.
“ExShell is a global leading digital financial exchange founded by two ex-senior executives of Huobi. The listing on Exshell is a new milestone for Longxing, it marks that the company is entering into the capital market and a new stage of development. We will make persistent efforts to constantly climb the peak.” Said by Oliver Ran, Chairman of TokenBit & Secretary General Director of Longxing.
A monumental carbon tax court case kicks off in the Saskatchewan Court of Appeal this week (Docket: CACV3239) as the Saskatchewan Party challenges the Canadian federal government on its carbon tax legislation, as reported by Global News, Feb. 10, 2019. This coincides with the release of a new report by Friends of Science Society entitled “Big Green Money vs Conventional Energy Advocates.”
The new report is critical of the ‘big green’ foreign-funding of environmental groups, many of which, like Ecojustice, a law charity representing intervenors in the carbon tax case, engage in ‘law-fare’ to block energy development and push for carbon taxes.
“Big Green Money…” report shows that common sense think tanks are vastly out-funded, out-lobbied and out-maneuvered by green billionaire foundations and their Environmental Non-governmental Organization (ENGO) fundees.
Robert Lyman authored the report which states that some .8 billion in foreign funding to Canadian ENGOs has been used to push the carbon tax and climate apocalypse agenda. Lyman is an Ottawa energy policy consultant and former public servant of 27 years, a diplomat for 10 years prior to that.
Most of the ENGOs reviewed in “Big Green Money…” have federal charitable status, thus subsidized by taxpayers. As reported by Global News, Aug. 30, 2018, one such charity, Ecojustice, successfully blocked Trans Mountain pipeline in the Federal Court of Appeals, resulting in the further loss of thousands of jobs in Alberta’s oil sands industry and other sectors.
As noted in the report, the National Energy Board publishes annual data on total investment (i.e. domestic and foreign) in the upstream Canadian oil industry. Investment in oil sands was .6 billion, down 60% from the peak level of annual investment of .4 billion in 2014.
Friends of Science says a carbon tax is irrelevant to climate change issues as more and more research demonstrates that carbon dioxide is not the control knob that can fine tune climate. They say the UN Climate Panel (IPCC) reports relied upon by proponents of the tax are based on Faulty Premises, as detailed in their Oct. 30, 2018 report by the same name.
As revealed by Donna Laframboise in her book “The Delinquent Teenager,” UN Climate Panel reports are heavily infiltrated by green activists from Greenpeace and WWF, whose organizations have been funded for millions of dollars by the billionaire ClimateWorks Foundation and partners who are pushing a global cap and trade system, as reported by Matthew Nisbet (2018) in “Strategic philanthropy in the post?Cap?and?Trade years: Reviewing U.S. climate and energy foundation funding“.
Friends of Science Society says a global carbon tax would be a road to ruin.
Another recent Friends of Science report issued Feb. 5, 2019, entitled “Carbon Pricing Consequences for Alberta” reveals a trail of destruction following the implementation of the provincial carbon tax.
Human industrial carbon dioxide emissions have greened the planet according to an April 26, 2016, NASA report. Growing climate science consensus shows carbon dioxide’s impact on warming to be nominal says French Emeritus Professor of physics, François Gervais.
Friends of Science Society is an independent group of earth, atmospheric and solar scientists, engineers, and citizens who are celebrating its 16th year of offering climate science insights. After a thorough review of a broad spectrum of literature on climate change, Friends of Science Society has concluded that the sun is the main driver of climate change, not carbon dioxide (CO2).
Sheyene Gerardi, a well-known Venezuelan soap opera star and model, has been appointed a member of NASA’s Center for Lunar and Asteroid Surface Science (CLASS) as the Lead for Robotics Outreach. This world-class institution of planetary scientists and space technologists invited Sheyene to join them because of her visionary work fusing space robotics technology development with humanitarian development on Earth.
Sheyene’s program addresses technological literacy in under-developed regions, creation of jobs in robotics, and advancement of technologies needed off-Earth. The program addresses a much larger concern, too, one that few have even considered: robotic industry on the Moon and Mars has such great potential for rapid scale-up that it could widen the gap between privileged and under-privileged to the point of causing great harm. Sheyene’s team is working to broaden the ownership of in-space industry as it develops, which will help solve all these problems.
Sheyene founded and operates a school to serve at-risk youth in an under-developed region of Venezuela. There, she has found systemic problems due to inadequate community support for education. Sheyene realized innovative methods are needed to motivate her students when she found out most of the children have very little hope for advancement in jobs or careers, and they do not see how education will change that.
In 2017, she met with the University of Central Florida. Sheyene recognized the space industry has great potential to improve life on Earth, but there is a strong chance the plight of people in underdeveloped regions will grow worse instead of better.
The concern is that once a supply chain is established through robots mining and manufacturing on the Moon or asteroids, it is outside the social and economic controls we have evolved for civilization on Earth. Within a few decades, advances in machine intelligence will make the robotics more autonomous, reducing the cost of labor to control the robots from Earth. According to a 2012 NASA study, it takes about this same amount of time for industry on the Moon or Mars to become an adequately self-sufficient supply chain to enable affordable scale-up, reducing the mass of materials that must be launched from Earth. The marginalization of labor from economic production is already a concern for terrestrial industry, but in space the isolation from normal economic and social restraints makes it much worse. Robotic space industry has potential to grow according to its “metabolism”, its throughput of matter and energy, without the usual economic and social controls. This can rapidly widen the gap between capital and labor, or between privileged and under-privileged following the lines of those who can participate in space and those cannot. Studies suggest this can occur as early as the middle of the century.
“As the economic revolution proceeds and production begins shifting first to robots on Earth and then to robots off-Earth, workers who don’t share ownership of the robots will be reduced to political powerlessness far worse than their conditions today. We have the opportunity to solve this problem during the bootstrapping period while human labor is still needed for space industry,” Sheyene says. Sheyene has added to this vision the theme of entertainment, to connect the creative community with scientists and thus educate the public to support science. “I also came to believe I can have the greatest impact for change by focusing on my area of expertise: what entertainment contributes to solving these problems: a lot, as it turns out, we have the ability to show people what they can do to address these problems widely and efficiently. I have been working with my production and marketing team to develop an ‘educational entertainment production for social change.’ My team sees fantastic opportunities to produce content in and around the program we have started,” she added.
Sheyene’s concern for the plight of the economically disadvantaged grew out of her unique life story. She started as an actress and became internationally-known for her roles in Spanish telenovelas until she was struck by serious personal tragedy. A year after losing her family in an automobile crash, she was diagnosed with a Stage 4 lymphoma that had spread to 85% of her body. She survived after three years of difficult chemotherapy to become the only know survivor of a rare form of the disease. These experiences convinced her to focus the rest of her life on helping people in need. She founded and now operates two non-profit philanthropic foundations including Sheyene School, which began in Venezuela and has now expanded into multiple countries to expand technological literacy and to create a pipeline to jobs and economic participation in underdeveloped regions. Sheyene recently started a socially-conscious business to broaden the ownership of space industry as one of its major goals. The business plans to accelerate human expansion into space by advancing the robotic technologies, doing so in a way that conveys equity to all the participants.
Shashi Jain, from TiE young entrepreneurs, said of Sheyene’s work, “As a Senior Technical Marketing Engineer for over 18 years, I am deeply impressed by the value of the work that Sheyene is doing through her non-profit. She understands how to inspire people to not just love the subject matter, but to see the possibility of contributing to it in themselves through a few simple steps. This is a rare skill; you often get two of these at the same time, not all three.”
Sheyene’s work advancing robotics education globally resulted in her invitation to join the planetary scientists of NASA’s CLASS. The CLASS team consists of leading planetary scientists, geologists, geochemists, dynamicists, engineers, physicists and other researchers from across the world, and is headed by Prof. Daniel T. Britt at the University of Central Florida. The CLASS network incorporates domestic institutions across the USA and international partner institutions in different countries. An integral part of the CLASS mission is to give back to the wider community.
“I have been following with great interest Sheyene’s activities in organizing world-wide robotics competitions. Her vision for expanding the scope and the impact of space science and engineering outreach dovetails strongly with the objectives of the Center for Lunar and Asteroid Surface Science. We are looking forward to working with Sheyene and are excited about the possibilities of the robotic competitions,” Prof. Daniel Britt said.
“People, in general, are unaware of the danger they are in, that with no way to personally go into space, no need for their labor in the face of robotic artificial intelligence, and no way to gain an ownership share in the industry, they will be left behind both economically and politically, creating a vastly deeper rift between the ‘Haves’ and the ‘Have-nots’. While the rift is already big today, it is seriously nothing compared to what it will be when industry is started in space and grows to massive proportions, unless steps are taken during the startup period,” Sheyene says. “Many solutions require an understanding of local pain points to solve economic and standard of living challenges every country is trying to solve to provide a better quality of life. I am glad and appreciative that with this synergy we can turn this initiative into a win for everyone. I feel the time is right,” she added.
Sheyene is advancing her plan to support both technological literacy and direct participation in space, through a robotics curriculum, which will be made freely available through her non-profit school. The team is also creating a series of robotics competitions, including secondary, college, and post-college events, with the goal of replicating it on a global scale. The technological progress achieved through the robotics competitions will be funneled back to NASA missions through her position in CLASS. Her participation with the SSERVI/CLASS network will facilitate her access to its cutting-edge scientific advances, enhancing the existing partnership she has with the Florida Space Institute, enabling her program to reach more people with the excitement of NASA space exploration to make a tangible difference their lives.
After the resounding success on the French Riviera, the Italian artist Cesare Catania continues to amaze international critics.
Thursday 19 July 2018, during the art biennial of Saint Paul de Vence, the last sculpture of Cesare Catania, entitled "The Heart of the Earth - B Version" will be installed right at the entrance to the Provençal village. It's a sculpture of contemporary art that connects to a previous work of art in wood and acrylic made by the same artist between the years 2012 and 2015, entitled "The Heart of the Earth - A Version". The last sculpture "The Heart of the Earth - B Version" draws inspiration from the same concept of strength and energy that releases the Earth and was made of Carrara marble powder and white cement. To give even greater emphasis to the energy aspect, the artist wanted to combine the remains of a meteorite in the mixture. The origin of the latter and the historical dating of the body
from thousands of light years are controversial: the only certain data is that they are fragments belonging to the meteorite cataloged by the official bodies and by NASA as "Meteorite Gibeon", fallen in prehistoric times in the southern region of Namibia (Africa) and some pieces of which are exhibited in the most famous geology museums in the world.
In this work of art Cesare Catania wanted to concentrate all the strength of the elements considered to be of greater energetic impact: the inverted pyramide and the sphere, the marble dust coming from the Earth and the meteorite fragments coming from the Universe.
The sculpture will be installed on Thursday 19 July 2018 in the heart of Provence and in particular in the capital of world art Saint Paul de Vence, in front of the contemporary art gallery Odd Gallery.
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